Well, if you choose the old main line of 5. Bg5, you have to contend with the Moscow/Anti-Moscow, Botvinnik, and Cambridge Springs. The Moscow/Anti-Moscow is the soundest option for Black, while the Botvinnik is riskier, but probably the most forcing route to equality.
If you choose the mainline Meran, 8...a6 will be the most challenging reply. Then Black has his fair share of fun after both 10. e5 and 10. d5, and White hasn't been able to prove an advantage anywhere, as usual.
Probably the most challenging option nowadays is to go for the Anti-Meran lines with 6. Qc2 and 7. Bd3. After 9...b5, both 10. Bd3 and 10. Be2 has been thoroughly discussed, with the verdict being equality after precise play by both sides in the main lines. I would recommend looking into the Anti-Meran lines, especially the approaches with an immediate 11. e4.
Of course, if Black uses the Slav move-order, I think both the Slav Exchange and Slow Slav are very decent options for White to avoid the Semi-Slav. If Black uses the Queen's Gambit move-order, there's always the QGD Exchange.
Unfortunately, Black also has the Triangle move-order, where the Noteboom and Marshall Gambit have been holding up well for Black, so maybe the Catalan is the way to go. Ultimately, chess is equal, and it's just a matter of taste as to what the most testing lines are...