In general this DVD set seems to have a bunch of holes in places, which is a shame.
The things Caru talks about things are all excellent (ok, he doesn't go into super depth and eg doesn't cover Gustafssons recommendation against 8.a4, but naturally you can't go over everything ever); if you actually do get one of his lines, you are good to go.
But then eg in the good old Steinitz defence, after 1.e4e5 2.Nf3Nc6 3.Bb5d6 4.d4exd4 5.Nxd4Bd7 6.0-0, he somehow only goes over 6..g6 followed by ..Ne7, not even mentioning the by far most popular Black setup (of 6..Nf6 followed by ..Be7); 8..Bd7 after 7..d6 8.a4 missing was mentioned in this thread already; and this feels like it carries through every line.
A random click into the first best video, accompanied with a DB: Open Spanish;
9.Qe2 has 407 games in the Lichess Master DB. 71x (2nd most popular move) 9..Bc5, 26x 9..Nc5.
9..Nc5 gets 25 minutes of coverage in the first video of the Open Defence; 9..Bc5 apparently deserves roughly 5 seconds ("10.Be3 Bxe3 Qxe3, Rd1 to follow" is all that Caru gives, with 10..Bxe3 already only being the third most popular move, at 11/55 games).
It's a treat to hear an SGM talk as always, but this certainly does not feel like a standalone complete repertoire.
Perhaps the series would've worked out a bit better if Caruana had focussed on actually laying out a repertoire, instead of talking at length about why he didn't choose variation X - so eg in the Open Spanish vid, there's 1.5 minutes of talk on current developments in 9.Nbd2; I personally would much rather have those 1.5 minutes spent on 9.Qe2 Bc5, something I will actually play and potentially encounter.
On the other hand, that type of general knowledge is of course always good to have, so who knows..
Overall, the Spanish is thankfully an opening, where omissions of concrete theory are rarely going to backfire badly for White, but I do think an Opening series shouldn't immediately leave me with a feel of "I would have liked better coverage of.. everything"
Perhaps it doesn't help that Spanish Mainline content has been undergoing an untterly dry spell, so rather than "I got 90% covered, and want some updates/alternatives on the critical lines", this was more of a "I want to learn everything" type of deal for me, but I do think that eg the Black series by Gustafsson vs 1.d4 @chess24 does its job of educating the viewer much better.
Pretty disappointed that I still don't even have a convincing solution that punishes Black for 3..d6
I do have to say though, that the original fear of Caruana lacking explanations and making a phonebook file series that's impossible to enjoy at sub-GM level was entirely unfounded.
Guidance is plenty, and following it is a breeze. He does a very good job at keeping the viewer engaged & able to watch multiple vids in a row, while retaining information & without breaking into a sweat.