JustinHorton - Thanks for the correction! Unfortunately, it's too late for me to go back and edit the original post.

cathexis - As aoc noted, none of Fischer's games with Keres was a Colle. You might be thinking of Keres-Fischer from the 15th round of the 1959 Candidates.  The game opened with 1.d4 Nf6 2.Nf3 g6 3.Bf4, which is a London, not a Colle.   

I did some searching of the Mega database for games where Fischer played Black and could have potentially faced a Colle System. A search of ECO codes D04-D05, which is the Colle from a 1.d4 d5 move order gave no hits. A45-A48, which covers the Colle and other Queen Pawn Games arising from 1.d4 Nf6, yielded five games: three with the Torre System, one Trompowsky, and the London with Keres mentioned above.

I also searched a few different opening sequences:
1.d4 Nf6 2.Nf3 g6 3.e3 - no hits
1.d4 Nf6 2.Nf3 e6 3.e3 - no hits
1.d4 d5 2.Nf3 - two games: Petrosian-Fischer, Candidates (23) 1959 transposed to a QGD Tartakower; Reshevsky-Fischer, Match (7) 1961 transposed to a Ragozin
1.d4 Nf6 2.Nf3 d5 - one game - Gudmundsson-Fischer, Reykjavik 1960. This game is the closest to a Colle that I could find. It happens to be Game 19 in My 60 Memorable Games. After opening with 1.d4 Nf6 2.Nf3 d5 3.e3 Bg7, Gudmundsson played 4.c4, and the game transposed into a Grünfeld. In his famous book, Fischer himself notes that 4.c3 would have produced a Colle.

It's pure speculation but we might be able to make a guess at how Fischer might have played against the Colle.  A search of his games with Black that opened with 1.d4 Nf6 2.Nf3 gives twenty games. In fourteen of these, he played 2...g6. So it seems likely that he would have gone for a fianchetto of his dark-square bishop, adopting a King's Indian approach, or possibly a Grünfeld as he did in the Gudmundsson game. Interestingly, 2...c5 was his second most favored continuation, with four games. Fischer's choice may have been influenced by the circumstances. Three of the games were played at Olympiads, so perhaps 2...c5 was an attempt to sharpen the game and go for a win against an opponent who was hoping for a draw by playing solidly.

Finally, there's the possibility that Fischer might have encountered the Colle in a game that isn't in the Mega database, such as from a simul. Perhaps a check of Donaldson's A Legend on the Road (a book I don't have) might turn up something.

Hello,

I am curious if and how Fischer played against the Colle. I think there was the game Fischer vs Keres, 1959 - Croatia. But were there others? 

P.S. I will be out-of-town for a few days, so I might not be able to respond right away, but please accept my thanks in advance.