Okay, I play both regularly so maybe I have some ideas
Najdorf: The Najdorf is extremely theoretical, and you need to bust your memory to survive. When I was 13 years old, I remember trying to memorise the 6. Bg5 Poisoned Pawn chapters of Nunn's old 1996 book. Thinking that it would never happen I just did it anyway for completeness. One day someone played one of the main lines and I needed it past move 25.
Then in 2003 a shocker was announced in the main line Poisoned Pawn with 15...Be7 with 17. Rf1!! and there was a mass of analyses in New In Chess (I think that it was this one, the YB), where it went past move 35 and even 40. I tried to analyse all of it but I lost twice against two titlted players because I just messed up my memory completely. My brain hard drive failed and lost in literally 45 minutes. My opponent told me, "YOu should have memorised the last New In Chess YB lines!"
Go to February 2015 and Negi has a almost 400 page book on 6. Bg5 for White. You have to memorise a lot of stuff as Black, but now there is the interesting 6...Sbd7. Still, you must be willing to bust yourself to memorise and memorise to play the Najdorf. There is also 6. Be3 and the extremely popular 6. h3, which seems to now have more theory than 6. Be2 at this rate.
My 6...Sbd7 ChessBase file is dated from November 2014 and is still on analyses. I often run the computer overnight with Stockfisk for critical lines. Sack is, are you willing to do this
Kan: I play the Kan with 5. Bd3 Bc5 6. Nb3 Be7, like Hellsten. I like it very much, and it is nowhere near theory of Najdorf. If you like to just play a setup Sicilian with (relatively!) lower thoery than the others and then counterattack in the moves between 15-25, then the Kan. Of course there is theory, but natural moves in my experience seems to be commoner in Kan than Najdorf because you do not really put Houdini and Stockfisk to move 40 in many Kan lines.
About 5. c4: this really does not scare me. I play the Hedgehog, but there is a very big difference. I hate the Maróczy Bind with the bishop on g7 (Accelerated Dragon setup) because ...d5 is alomst impossible. Hedgehod has pawns on d6 and e6 and you play for ...d5. White often gets overextended here, so if you are good in close quarters, just play the Hedgehog against 5. c4.